Latest Publications

It’s a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM.Mol Cell. 2022 Apr 20:S1097-2765(22)00319-7. doi: 10.1016/j.molcel.2022.04.008. Online ahead of print.PMID: 35487209

ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly. Arguello T, Peralta S, Antonicka H, Gaidosh G, Diaz F, Tu YT, Garcia S, Shiekhattar R, Barrientos A, Moraes CT.Cell Rep. 2021 Dec 21;37(12):110139. doi: 10.1016/j.celrep.2021.110139.PMID: 34936866

Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA.Nature. 2021 Nov;599(7885):485-490. doi: 10.1038/s41586-021-04075-0. Epub 2021 Nov 10.PMID: 34759321

Integrator enforces the fidelity of transcriptional termination at protein-coding genes. Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J, Kirstein N, Tayari MM, Shilatifard A, Shiekhattar R.Sci Adv. 2021 Nov 5;7(45):eabe3393. doi: 10.1126/sciadv.abe3393. Epub 2021 Nov 3.PMID: 34730992

Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells. Ayupe AC, Beckedorff F, Levay K, Yon B, Salgueiro Y, Shiekhattar R, Park KK.BMC Genomics. 2021 Oct 14;22(1):741. doi: 10.1186/s12864-021-08050-x.PMID: 34649511

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis. Shersher E, Lahiry M, Alvarez-Trotta A, Diluvio G, Robbins DJ, Shiekhattar R, Capobianco AJ.Cell Commun Signal. 2021 Sep 22;19(1):96. doi: 10.1186/s12964-021-00776-1.PMID: 34551776

RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells. Sun J, Gaidosh G, Xu Y, Mookhtiar A, Man N, Cingaram PR, Blumenthal E, Shiekhattar R, Goka ET, Nimer SD, Lippman ME.Oncogene. 2021 Oct;40(40):5950-5962. doi: 10.1038/s41388-021-01985-1. Epub 2021 Aug 9.PMID: 34373577

Erratum to: A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement. Rebelo AP, Cortese A, Abraham A, Eshed-Eisenbach Y, Shner G, Vainshtein A, Buglo E, Camarena V, Gaidosh G, Shiekhattar R, Abreu L, Courel S, Burns DK, Bai Y, Bacon C, Feely SME, Castro D, Peles E, Reilly MM, Shy ME, Zuchner S.Brain. 2021 Aug 17;144(7):e64. doi: 10.1093/brain/awab181.PMID: 34037698

Protein Kinase D-Dependent Downregulation of Immediate Early Genes through Class IIA Histone Deacetylases in Acute Lymphoblastic Leukemia. Sun G, Shvab A, Leclerc GJ, Li B, Beckedorff F, Shiekhattar R, Barredo JC.Mol Cancer Res. 2021 Aug;19(8):1296-1307. doi: 10.1158/1541-7786.MCR-20-0808. Epub 2021 May 12.PMID: 33980612

A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement. Rebelo AP, Cortese A, Abraham A, Eshed-Eisenbach Y, Shner G, Vainshtein A, Buglo E, Camarena V, Gaidosh G, Shiekhattar R, Abreu L, Courel S, Burns DK, Bai Y, Bacon C, Feely SME, Castro D, Peles E, Reilly MM, Shy ME, Zuchner S.Brain. 2021 May 7;144(4):1197-1213. doi: 10.1093/brain/awab019.PMID: 33889941

Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies. Tayari MM, Santos HGD, Kwon D, Bradley TJ, Thomassen A, Chen C, Dinh Y, Perez A, Zelent A, Morey L, Cimmino L, Shiekhattar R, Swords RT, Watts JM.Clin Cancer Res. 2021 Apr 1;27(7):1893-1903. doi: 10.1158/1078-0432.CCR-20-4054. Epub 2021 Jan 25.PMID: 33495312

The Integrator complex at the crossroad of coding and noncoding RNA. Kirstein N, Gomes Dos Santos H, Blumenthal E, Shiekhattar R.Curr Opin Cell Biol. 2021 Jun;70:37-43. doi: 10.1016/j.ceb.2020.11.003. Epub 2020 Dec 16.PMID: 33340967

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1. Barra J, Gaidosh GS, Blumenthal E, Beckedorff F, Tayari MM, Kirstein N, Karakach TK, Jensen TH, Impens F, Gevaert K, Leucci E, Shiekhattar R, Marine JC.Sci Adv. 2020 Jul 3;6(27):eaaz9072. doi: 10.1126/sciadv.aaz9072. eCollection 2020 Jul.PMID: 32923585.

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts. Beckedorff F, Blumenthal E, daSilva LF, Aoi Y, Cingaram PR, Yue J, Zhang A, Dokaneheifard S, Valencia MG, Gaidosh G, Shilatifard A,Shiekhattar R.Cell Rep. 2020 Jul 21;32(3):107917. doi: 10.1016/j.celrep.2020.107917.PMID: 32697989.

Targeted chemotherapy overcomes drug resistance in melanoma. Yue J, Vendramin R, Liu F, Lopez O, Valencia MG, Gomes Dos Santos H, Gaidosh G, Beckedorff F, Blumenthal E, Speroni L, Nimer SD, Marine JC, Shiekhattar R.Genes Dev. 2020 May 1;34(9-10):637-649. doi: 10.1101/gad.333864.119. Epub 2020 Apr 2.PMID: 3224180.

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release. Aoi Y, Smith ER, Shah AP, Rendleman EJ, Marshall SA, Woodfin AR, Chen FX, Shiekhattar R, Shilatifard A.Mol Cell. 2020 Apr 16;78(2):261-274.e5. doi: 10.1016/j.molcel.2020.02.014. Epub 2020 Mar 9.PMID: 32155413.

TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L, Sun X, Figueroa M, Shiekhattar R, Nimer S.Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z.

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. Chan HL, Beckedorff F, Zhang Y, Garcia-Huidobro J, Jiang H, Colaprico A, Bilbao D, Figueroa ME, LaCava J, Shiekhattar R, Morey L. Nat Commun. 2018 Aug 23;9(1):3377.

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Amaral PP, Leonardi T, Han N, Viré E, Gascoigne DK, Arias-Carrasco R, Büscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genome Biol. 2018 Mar 15;19(1):32.

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Genes Dev. 2017 Sep 1;31(17):1809-1820.

PAF1 regulation of promoter-proximal pause release via enhancer activation. Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A. Science. 2017 Sep 22;357(6357):1294-1298.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL. Cell. 2017 Jan 12;168(1-2):135-149.e22.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. Sci Adv. 2016 Sep 2;2(9):e1601167.

Diverse regulatory interactions of long noncoding RNAs. Kim TK, Shiekhattar R. Curr Opin Genet Dev. 2016 Feb;36:73-82.

Architectural and Functional Commonalities between Enhancers and Promoters. Kim TK, Shiekhattar R. Cell. 2015 Aug 27;162(5):948-59.

Integrator mediates the biogenesis of enhancer RNAs. Lai F, Gardini A, Zhang A, Shiekhattar R. Nature. 2015 Sep 17;525(7569):399-403.

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A. Cell. 2015 Aug 27;162(5):1003-15.

The many faces of long noncoding RNAs. Gardini A, Shiekhattar R. FEBS J. 2015 May;282(9):1647-57.

Regulation of transcription by long noncoding RNAs. Bonasio R, Shiekhattar R. Annu Rev Genet. 2014;48:433-55.

Integrator regulates transcriptional initiation and pause release following activation. Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. Mol Cell. 2014 Oct 2;56(1):128-139.

Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia. Rocha-Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L. Mol Cell Biol. 2014 Oct 1;34(19):3765-75.

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation. Gardini A, Baillat D, Cesaroni M, Shiekhattar R. EMBO J. 2014 Apr 16;33(8):890-905. Erratum in: EMBO J. 2014 Sep 17;33(18):2134.

Where long noncoding RNAs meet DNA methylation. Lai F, Shiekhattar R. Cell Res. 2014 Mar;24(3):263-4.

Enhancer RNAs: the new molecules of transcription. Lai F, Shiekhattar R. Curr Opin Genet Dev. 2014 Apr;25:38-42.