PUBLICATIONS 2018-03-01T16:13:23+00:00

Latest Publications

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Genes Dev. 2017 Sep 1;31(17):1809-1820. doi: 10.1101/gad.301697.117.

PAF1 regulation of promoter-proximal pause release via enhancer activation. Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A. Science. 2017 Sep 22;357(6357):1294-1298. doi: 10.1126/science.aan3269. Epub 2017 Aug 31.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL. Cell. 2017 Jan 12;168(1-2):135-149.e22. doi: 10.1016/j.cell.2016.12.020. Epub 2017 Jan 12.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. Sci Adv. 2016 Sep 2;2(9):e1601167. doi: 10.1126/sciadv.1601167. eCollection 2016 Sep.

Diverse regulatory interactions of long noncoding RNAs. Kim TK, Shiekhattar R. Curr Opin Genet Dev. 2016 Feb;36:73-82. doi: 10.1016/j.gde.2016.03.014. Epub 2016 May 3.

Architectural and Functional Commonalities between Enhancers and Promoters. Kim TK, Shiekhattar R. Cell. 2015 Aug 27;162(5):948-59. doi: 10.1016/j.cell.2015.08.008.

Integrator mediates the biogenesis of enhancer RNAs. Lai F, Gardini A, Zhang A, Shiekhattar R. Nature. 2015 Sep 17;525(7569):399-403. doi: 10.1038/nature14906. Epub 2015 Aug 26.

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A. Cell. 2015 Aug 27;162(5):1003-15. doi: 10.1016/j.cell.2015.07.042. Epub 2015 Aug 13.

The many faces of long noncoding RNAs. Gardini A, Shiekhattar R. FEBS J. 2015 May;282(9):1647-57. doi: 10.1111/febs.13101. Epub 2014 Nov 7.

Regulation of transcription by long noncoding RNAs. Bonasio R, Shiekhattar R. Annu Rev Genet. 2014;48:433-55. doi: 10.1146/annurev-genet-120213-092323. Epub 2014 Sep 18.

Integrator regulates transcriptional initiation and pause release following activation. Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. Mol Cell. 2014 Oct 2;56(1):128-139. doi: 10.1016/j.molcel.2014.08.004. Epub 2014 Sep 4.

Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia. Rocha-Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L. Mol Cell Biol. 2014 Oct 1;34(19):3765-75. doi: 10.1128/MCB.00839-14. Epub 2014 Jul 28.

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation. Gardini A, Baillat D, Cesaroni M, Shiekhattar R. EMBO J. 2014 Apr 16;33(8):890-905. doi: 10.1002/embj.201385567. Epub 2014 Mar 3. Erratum in: EMBO J. 2014 Sep 17;33(18):2134.

Where long noncoding RNAs meet DNA methylation. Lai F, Shiekhattar R. Cell Res. 2014 Mar;24(3):263-4. doi: 10.1038/cr.2014.13. Epub 2014 Jan 31.

Enhancer RNAs: the new molecules of transcription. Lai F, Shiekhattar R. Curr Opin Genet Dev. 2014 Apr;25:38-42. doi: 10.1016/j.gde.2013.11.017. Epub 2014 Jan 28.