PUBLICATIONS 2020-12-08T19:38:38+00:00

Latest Publications

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1. Barra J, Gaidosh GS, Blumenthal E, Beckedorff F, Tayari MM, Kirstein N, Karakach TK, Jensen TH, Impens F, Gevaert K, Leucci E, Shiekhattar R, Marine JC.Sci Adv. 2020 Jul 3;6(27):eaaz9072. doi: 10.1126/sciadv.aaz9072. eCollection 2020 Jul.PMID: 32923585.

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts. Beckedorff F, Blumenthal E, daSilva LF, Aoi Y, Cingaram PR, Yue J, Zhang A, Dokaneheifard S, Valencia MG, Gaidosh G, Shilatifard A,Shiekhattar R.Cell Rep. 2020 Jul 21;32(3):107917. doi: 10.1016/j.celrep.2020.107917.PMID: 32697989.

Targeted chemotherapy overcomes drug resistance in melanoma. Yue J, Vendramin R, Liu F, Lopez O, Valencia MG, Gomes Dos Santos H, Gaidosh G, Beckedorff F, Blumenthal E, Speroni L, Nimer SD, Marine JC, Shiekhattar R.Genes Dev. 2020 May 1;34(9-10):637-649. doi: 10.1101/gad.333864.119. Epub 2020 Apr 2.PMID: 3224180.

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release. Aoi Y, Smith ER, Shah AP, Rendleman EJ, Marshall SA, Woodfin AR, Chen FX, Shiekhattar R, Shilatifard A.Mol Cell. 2020 Apr 16;78(2):261-274.e5. doi: 10.1016/j.molcel.2020.02.014. Epub 2020 Mar 9.PMID: 32155413.

TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L, Sun X, Figueroa M, Shiekhattar R, Nimer S.Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z.

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. Chan HL, Beckedorff F, Zhang Y, Garcia-Huidobro J, Jiang H, Colaprico A, Bilbao D, Figueroa ME, LaCava J, Shiekhattar R, Morey L. Nat Commun. 2018 Aug 23;9(1):3377.

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Amaral PP, Leonardi T, Han N, Viré E, Gascoigne DK, Arias-Carrasco R, Büscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genome Biol. 2018 Mar 15;19(1):32.

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Genes Dev. 2017 Sep 1;31(17):1809-1820.

PAF1 regulation of promoter-proximal pause release via enhancer activation. Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A. Science. 2017 Sep 22;357(6357):1294-1298.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL. Cell. 2017 Jan 12;168(1-2):135-149.e22.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. Sci Adv. 2016 Sep 2;2(9):e1601167.

Diverse regulatory interactions of long noncoding RNAs. Kim TK, Shiekhattar R. Curr Opin Genet Dev. 2016 Feb;36:73-82.

Architectural and Functional Commonalities between Enhancers and Promoters. Kim TK, Shiekhattar R. Cell. 2015 Aug 27;162(5):948-59.

Integrator mediates the biogenesis of enhancer RNAs. Lai F, Gardini A, Zhang A, Shiekhattar R. Nature. 2015 Sep 17;525(7569):399-403.

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A. Cell. 2015 Aug 27;162(5):1003-15.

The many faces of long noncoding RNAs. Gardini A, Shiekhattar R. FEBS J. 2015 May;282(9):1647-57.

Regulation of transcription by long noncoding RNAs. Bonasio R, Shiekhattar R. Annu Rev Genet. 2014;48:433-55.

Integrator regulates transcriptional initiation and pause release following activation. Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. Mol Cell. 2014 Oct 2;56(1):128-139.

Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia. Rocha-Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L. Mol Cell Biol. 2014 Oct 1;34(19):3765-75.

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation. Gardini A, Baillat D, Cesaroni M, Shiekhattar R. EMBO J. 2014 Apr 16;33(8):890-905. Erratum in: EMBO J. 2014 Sep 17;33(18):2134.

Where long noncoding RNAs meet DNA methylation. Lai F, Shiekhattar R. Cell Res. 2014 Mar;24(3):263-4.

Enhancer RNAs: the new molecules of transcription. Lai F, Shiekhattar R. Curr Opin Genet Dev. 2014 Apr;25:38-42.